withanolide |
The Substance: Withanolides can be found in the Indian herbal medicine Ashwagandha. Ashwagandha is a powder derived from the root of the plant of the same name. Withanolides are currently being explored for their brain regenerative properties. Medicinal Properties:
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Scientific Data:
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The Plant:
Ashwagandha (Withania Somnifera) is a plant from the Solanaceae or Nightshade family which includes the Potatoe, Tomato and Deadly Nightshade species. It grows as a stout shrub that reaches a height of 170cm. Like the tomato, ashwagandha bears yellow flowers and red fruit, though its fruit has the size and shape of a berry. Ashwagandha grows abundantly in India, Pakistan, and Sri Lanka. |
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Historical Uses: The leaves and berries of Ashwagandha have been in use for centuries in India. The extract is an important part of Indian Ayurvedic medicine. It has been used in the following ways:
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Quotations from Recent Research Abstracts |
Abstract 1 (2005): Withanolide plus Withanoside and Reconstruction of Neuronal Networks. Title: Search for natural products related to regeneration of the neuronal network. Neurosignals. 2005;14(1-2):34-45; Abstract 2 (April 2005): Withanolide and Neuritic Regeneration and Synaptic Reconstruction. Title: Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144(7):961-71. Abstract 3 (Oct 2002): Withanolides and Axon- and Dendrite- Outgrowth. Title: Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. Neuroreport. 2002 Oct 7;13(14):1715-20. Abstract 4 (June 2002): Withanolides and Neurite Outgrowth.
Title: Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem Pharm Bull (Tokyo). 2002 Jun;50(6):760-5.
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Old Herbs - New Science | ||
Ananain and Comosain (from Pineapple stem) Cinnamon Extract Curcuma Longa Curcumenol Ficain (from Fig Trees) Licorice Root Extract Petty Spurge and Euphorbia Peplus |
Rosmarinic Acid (from Rosemary, Sage) Spanish Sage Turmeric Extract Vineatrol (from Grapevine shoots) Withania Somnifera (Ashwagandha) Withanolide (from Ashwagandha) Zerumbone (from Ginger) |
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